Medically reviewed by Debra Sullivan, Ph. Trying to squeeze them will only cause further inflammation and may cause scarring. To ease the pain and inflammation of acne nodules, try applying ice wrapped in a soft cloth to the affected area a few times a day. If the cause is an infection, the swelling should go away within 1—2 weeks. Benign epithelial tumors, hamartomas, and hyperplasias.
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