Phone: Email: immunopharma77 at gmail. A negative result means no CCP antibodies were found. Although the vertebrae are the major site of involvement in the skeletal system, peripheral joint involvement can also occur. ACPA bind to osteoclast surfaces, resulting in osteoclastogenesis and bone degradation [ 4 ]. IgM-RF specificity increases considerably at high titres [ 4 , 10 , 12 ].
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