Rosalind Franklin of DNA structure fame took on the study of TMV structure using the then-new method of isomorphous replacement to first, in , locate the RNA within virions , and then in with Kenneth Holmes , to determine that the virions were indeed helical in structure — something first proposed by James Watson in , although he did not see they were also hollow. Google Scholar PubMed. Toggle limited content width. For the first time, a system has been made available which permits the unambiguous analysis of the molecular basis underlying the replication of a self-propagating nucleic acid. Main article: Vaccine contamination with SV
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