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Baltimore longitudinal study of aging. The difference between the decline of total T and free T during the aging process is explained by an age-related increase in circulating concentration of sex hormone-binding globulin SHBG , which reduces the proportion of free T 16 , Although testosterone may make prostate cancer grow, it is not clear that testosterone treatment actually causes cancer. Hum Reprod. Products and services. MedStar Health Blog. Testosterone therapy in men with hypogonadism: an endocrine society clinical practice guideline.

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