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Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Effect of other agents on the pharmacokinetics of aprepitant. In addition, two serious drug related adverse experiences were reported in PONV clinical studies in patients taking a higher dose of aprepitant: one case of constipation and one case of subileus. Coadministration of Emend with warfarin may result in a clinically significant decrease in international normalised ratio INR of prothrombin time. Patient randomization will be stratified by grade of tumor 1 or 2 versus 3 or 4 and the number of prior progressions 0 or 1 versus 2. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This results in the desired isomer crystallizing on the top of the solution and the unwanted isomer remaining in the solution.

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