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Four weeks of caffeine ingestion resulted in increased tolerance to acute caffeine supplementation in previously low habitual caffeine consumers, with the ergogenic effect of acute caffeine supplementation no longer apparent [ ]. Although caffeine is associated with sleep disturbances, caffeine has also been shown to improve vigilance and reaction time and improved physical performance after sleep deprivation [ , , , , ]. Eur J Cardiovasc Prev Rehabil. Calling for an end to racial injustice on the East Carolina campus, Newman Club members initiated a petition for ra- cial equality. Additionally, regular physical activity appears to attenuate the increase in blood pressure induced by caffeine ingestion, but only in individuals with the AA genotype [ ].

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